By Dr. Troy Veale, CEO, PHD Laboratory
When 78-year-old Margaret began forgetting words, feeling dizzy, and sleeping more than usual, her daughter assumed it was just aging. But Margaret knew something wasn’t right. She had recently started a new antidepressant, and instead of feeling better, she felt foggy, unstable, and disconnected.
A home health nurse suggested PHD Laboratory’s pharmacogenomic (PGx) testing—a simple cheek swab that shows how genes influence medication response. The results revealed that Margaret’s genetic variation slowed her metabolism of the antidepressant, causing it to build up in her system and trigger her symptoms.
Her doctor adjusted her prescription based on the PGx results. Within two weeks, Margaret was back in her garden, cooking for neighbors, and enjoying her senior center’s weekly card games. Her daughter later said, “It felt like we got Mom back.”
What Is PGx Testing?
PGx testing uses a simple DNA sample to show how your body absorbs, breaks down, and responds to medications. Instead of trial-and-error prescribing, it allows providers to choose drugs and doses that are safer and more effective—personalized medicine at its best.
Why PGx Testing Matters for Older Adults
Aging adults often take multiple prescriptions for conditions like heart disease, diabetes, pain, depression, insomnia, or anxiety. Multiple medications increase the risk of:
• Adverse drug reactions (ADRs)
• Unintended side effects
• Ineffective treatment
• Dangerous interactions
According to the CDC, older adults take an average of four to five prescriptions daily. PGx testing helps providers anticipate responses and prevent complications before prescribing.
Benefits of PGx Testing
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Reduces Trial and Error – Find the right medication quickly.
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Prevents Adverse Drug Reactions – Identify drugs that may be harmful or poorly tolerated.
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Improves Effectiveness – Medication aligns with genetics for predictable results.
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Supports Overall Wellness – Ensures safer choices for memory, mood, sleep, and pain medications.
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Enhances Care Coordination – Results can be shared with doctors, pharmacists, and care teams.
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Supports Aging in Place – Safe, effective medication reduces hospital visits and preserves independence.
Who Should Consider PGx Testing?
• Older adults on multiple prescriptions
• Anyone experiencing unexplained side effects
• Patients starting medications for depression, anxiety, pain, or heart conditions
• Caregivers seeking clarity and safety
• Providers caring for aging adults
Even long-standing medications may be impacted by genetics—long-term symptoms could be resolved with PGx testing insight.
How the Test Works
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A simple cheek swab is collected.
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Genetic variants related to medication metabolism are analyzed.
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A detailed report is shared with the provider.
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Medications and doses are adjusted accordingly.
Many PGx tests are covered by Medicare Part B, often at little to no cost.
A Smarter, Safer Approach to Medication
PGx testing transforms medication management from guesswork into science. Just like Margaret, many seniors experience remarkable improvement when their medications finally match their biology.
The right medication can change a life. PGx testing helps you find it with confidence, safety, and precision.
PHD Laboratory
E: inquiry@phdlaboratory.com
P: 704.565.0870
W: phdlaboratory.com
